David O’Keefe

B.S., Biological Sciences, Stanford University (1990)dave3
Ph.D., Neurosciences, University of California, San Diego (2000)
Postdoctoral Studies, Salk Institute, La Jolla, CA (2000-2002) and Fred Hutchinson Cancer Research Center, Seattle, WA (2002-2007)

Staff Scientist, Fred Hutchinson Cancer Research Center (2007-2010)
Scientific Writer, pzerofive Editing (2010-present)

Dr. O’Keefe has spent the past twenty years studying and writing about developmental biology, cancer biology, and neuroscience. He has published numerous articles in prestigious journals and authored grants that have been funded by both public and private agencies. Since 2010 he has worked full time as an editor and writer, helping scientists reach a global audience, regardless of their nationality or upbringing.

Areas of expertise: biomedical science, cancer biology, cell biology, development, genetics, genomics, and neuroscience

Selected Publications:
O’Keefe DD
, Thomas S, Edgar BA. Buttitta LA (2014). Temporal regulation of Dpp signaling output in the Drosophila wing. Dev Dyn 243, 818–832.

O’Keefe DD, Thomas SR, Bolin K, Edgar BA, Buttitta LA (2012). Combinatorial control of temporal gene expression in the Drosophila wing by enhancers and core promoters. BMC Genomics 13, 498.

O’Keefe DD, Gonzalez-Nino E, Edgar BA, Curtiss J (2012). Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila. Dev Biol 369, 223–234.

O’Keefe DD, Edgar BA, Saucedo LJ (2011). EndoGI modulates Notch signaling and axon guidance in Drosophila. Mech Dev 128, 59–70.

O’Keefe DD, Gonzalez-Nino E, Burnett M, Dylla L, Lambeth SM, Licon E, Amesoli C, Edgar BA, Curtiss J (2009). Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol 333, 143–160.

O’Keefe DD, Prober DA, Moyle PS, Rickoll WL, Edgar BA (2007). Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing. Dev Biol 311, 25–39.

Mindorff EN, O’Keefe DD, Labbe A, Yang JP, Ou Y, Yoshikawa S, van Meyel DJ (2007). A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein Dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Genetics 176, 2247–2263.

Labrador JP, O’Keefe D, Yoshikawa S, McKinnon RD, Thomas JB, Bashaw GJ (2005). The homeobox transcription factor Even- skipped regulates Netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Curr Biol 15, 1413–1419.

O’Keefe DD, Thomas JB (2001). Drosophila wing development in the absence of dorsal identity. Development 128, 703–710.

van Meyel DJ, O’Keefe DD, Jurata LW, Thor S, Gill GN, Thomas JB (2000). Chip is an essential co-factor for Apterous in the regulation of axon guidance in Drosophila. Development 127, 1823–1831.

Bonkowsky JL, Yoshikawa S, O’Keefe DD, Scully AL, Thomas JB (1999). Axon routing across the midline controlled by the Drosophila Derailed receptor. Nature 402, 540–544.

Lilly B, O’Keefe DD, Thomas JB, Botas J (1999). The LIM homeodomain protein dLim-1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila. Mech Dev 88, 195–205.

van Meyel DJ, O’Keefe DD, Jurata LW, Thor S, Gill GN, Thomas JB (1999). Chip and Apterous physically interact to form a functional complex during Drosophila development. Mol Cell 4, 259–265.

O’Keefe DD, Thor S, Thomas JB (1998). Function and specificity of LIM domains in Drosophila nervous system and wing development. Development 125, 3915–3923.